Skip to main content
How Can We Help?
< All Topics
Print

Estradiol

Posted
Updated
ByEditor
  • Estradiol
    • Reference Range: 20 – 50
    • Units: pg/ml
    • Estradiol is the most potent of the three major human estrogens, being 12 times more potent than estrone and 80 times more potent than estriol [A-3]. Its activity is mediated through two receptor subtypes: estrogen receptor-alpha (ER-α) promotes breast cell proliferation, while ER-β inhibits it. Estradiol acts equally at both receptors, but when combined with estriol—which predominantly activates the protective ER-β—the proliferative risk is mitigated [A-3]. This is why experienced practitioners of bio-identical hormone replacement therapy (BHRT) typically prescribe estradiol and estriol in an 80:20 ratio, along with natural progesterone [A-3].
Table of Contents